⊛ learn · lesson 10
how smell works
from the air to the brain
two ways in.
breathe in, and scent molecules go up through your nostrils. eat, and they rise from your mouth through the back of your throat. both reach the same patch of tissue, high in the nose.
the path to the brain.
tap each stop.
a nobel for the nose.
in 1991, linda buck and richard axel described a huge family of genes, first found in rats, that looked like the code for smell receptors. in 2004 they shared the nobel prize in physiology or medicine.
a pattern, not a lock.
humans have several hundred working smell receptor genes. in mice, one molecule woke several receptors, and one receptor answered to several molecules. different smells made different patterns.
why you stop smelling your own perfume.
stay with a smell and it seems to get weaker, even if nothing has changed. scientists study this as adaptation, and they are still working out where in the system it happens.
true or not?
tap each one.
sources
- James et al. · Frontiers in Allergy 2022
- Özay et al. · Balkan Medical Journal 2019
- Bojanowski & Hummel · Physiology & Behavior 2012
- StatPearls · physiology, olfactory (NCBI)
- Kadohisa · Frontiers in Systems Neuroscience 2013
- Courtiol & Wilson · Frontiers in Neural Circuits 2015
- Burbach · the 2004 Nobel Prize for smell, 2004
- Buck & Axel · Cell 1991
- Fred Hutch · Linda Buck, Nobel Prize, 2004
- Niimura & Nei · Journal of Human Genetics 2006
- Malnic et al. · Cell 1999
- Dalton · Chemical Senses 2000
- Pellegrino et al. · Physiology & Behavior 2017
- Mignot et al. · European Archives of Oto-Rhino-Laryngology 2022
- Bobei et al. · Psychonomic Bulletin & Review 2026
- Hackländer et al. · Psychonomic Bulletin & Review 2019
- Bushdid et al. · Science 2014
- Gerkin & Castro · eLife 2015
- Meister · eLife 2015
- Spence · Flavour 2015